Sucuri have released a security advisory stating a DANGEROUS Persistent XSS Vulnerability in WP-Super Cache plugin used by Millions of Wordpress websites (according to wordpress.org).
The Vulnerability
This vulnerability could be leveraged by an attacker by creating a carefully crafted query, further used to insert malicious scripts to the plugin's cached file listing page.
"As this page requires a valid nonce in order to be displayed, a successful exploitation would require the sites administrator to have a look at that particular section, manually", states the report.
Attacker could simply create fresh administrator account to the site, inject bakcdoors by using WordPress theme edition tools, etc., upon successful execution of the injected scripts.
Technical Details
The issue lies in the way WP-Super-Cache would display information stored in cache files key, which is used by the plugin to decide what cache file must be loaded.

As you can see from the above, the $details[ key ] is directly appended to the pages content, without being sanitized first ($details[ uri ] is sanitized somewhere else, before this snippet).

As the key index of the $details variable contains theget_wp_cache_key() functions return (which contains data coming straight from the users cookies), an attacker can insert malicious scripts on the page.
Mitigation
An updated version of the plugin is available in which this vulnerability has been patched. The site admins are advised to update the WP-Super Cache plugin to latest available version i.e. 1.4.4.